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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Canrenone additionally increases the plasma level of potassium , lowers blood pressure and reduces preload.”
Clinical efficacy of potassium canreonate-canrenone in sinus rhythm restoration among patients with atrial fibrillation - a protocol of a pilot, randomized, double -blind, placebo-controlled study (CANREN-AF trial)“Regardless of the region, the participants with detectable canrenone concentrations had significant increases from baseline in potassium and aldosterone levels (a finding that is consistent with the expected effect of spironolactone), whereas the participants with undetectable canrenone concentrations did not (Fig. 1E and 1F).”
“We have also shown that canrenone is able to block directly the effect of aldosterone excess at the level of human mononuclear leukocytes in vitro, reducing cell volume, regulating the intracellular concentration of sodium and potassium , and blocking the inflammatory effect [11–13].”
Primary aldosteronism: considerations about the evaluation of the aldosterone to renin ratio during canrenone treatment
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