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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cannabinoids
drug:
Serotonin
Research Papers that Mention the Interaction
“Natural and synthetic cannabinoids differing in the pyrene ring of the hydro-phobic side chain or in steric configuration, inhibited differentially the saturation level of 5-HT uptake, the active uptake and the passive transport of the neurotransmitter, indicating multiple sites of action of the drugs.”
Cannabinoids and serotonin uptake by blood platelets: evidence for multiple sites of action.“The possible interactions between the cannabinoid and serotonin systems in the regions of the brain involved in emotional learning and memory formation have been studied by some researchers.”
“Interactions between the cannabinoid and serotonin systems have been reported in many studies.”
“The cannabinoid system has been implicated in control of mood and neural processing of emotional information, and the modulation of serotonin (5-HT) release in the synaptic clefts.”
“However, we hypothesized that it might not promote sociability in other strains due to cannabinoid CB(1 ) receptor-mediated inhibition of serotonin (5-HT) transmission in the frontal cortex.”
Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice“These findings suggest that systemically administered cannabinoids interact with descending serotonergic pathways via CB₁-mediated mechanisms and exert a central antinociceptive effect involving spinal 5-HT₇ and 5-HT(2A) receptors.”
“ Cannabinoids possible influence on 5-HT release in peripheral tissues may be clinically significant.”
“Our results show that cannabinoids and arachidonic acid inhibit DA and 5-HT uptake into rat neocortical synaptosomes.”
“Although some of these compounds do not possess typical Δ9-THC or marijuana-like effects in laboratory animals or humans, each of the cannabinoids tested, with one exception, inhibited the uptake of serotonin at the concentrations used.”
“Each of the cannabinoids which inhibited [3H]serotonin accumulation did so in a dose-responsive manner.”
“Taken together, our study suggests that cannabinoids may have direct and indirect effects on the 5-HT regulatory circuits, resulting in regionally selective changes of 5-HT efflux in the brain.”
“We showed that the direct effect of cannabinoids caused a reduction in 5-HT efflux whereas the indirect effect resulted in an increase.”
Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain
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