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Last Updated: a year ago

Possible Interaction: Cannabinoids and Serotonin

supplement:

Cannabinoids

Research Papers that Mention the Interaction

Natural and synthetic cannabinoids differing in the pyrene ring of the hydro-phobic side chain or in steric configuration, inhibited differentially the saturation level of 5-HT uptake, the active uptake and the passive transport of the neurotransmitter, indicating multiple sites of action of the drugs.
Biochemical pharmacology  •  1982  |  View Paper
The possible interactions between the cannabinoid and serotonin systems in the regions of the brain involved in emotional learning and memory formation have been studied by some researchers.
Brain Research  •  2016  |  View Paper
Interactions between the cannabinoid and serotonin systems have been reported in many studies.
Behavioural Brain Research  •  2015  |  View Paper
The cannabinoid system has been implicated in control of mood and neural processing of emotional information, and the modulation of serotonin (5-HT) release in the synaptic clefts.
European journal of pharmacology  •  2013  |  View Paper
However, we hypothesized that it might not promote sociability in other strains due to cannabinoid CB(1 ) receptor-mediated inhibition of serotonin (5-HT) transmission in the frontal cortex.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2012  |  View Paper
These findings suggest that systemically administered cannabinoids interact with descending serotonergic pathways via CB₁-mediated mechanisms and exert a central antinociceptive effect involving spinal 5-HT₇ and 5-HT(2A) receptors.
European journal of pharmacology  •  2010  |  View Paper
Cannabinoids possible influence on 5-HT release in peripheral tissues may be clinically significant.
Die Pharmazie  •  2009  |  View Paper
Our results show that cannabinoids and arachidonic acid inhibit DA and 5-HT uptake into rat neocortical synaptosomes.
Neurochemistry International  •  2004  |  View Paper
Although some of these compounds do not possess typical Δ9-THC or marijuana-like effects in laboratory animals or humans, each of the cannabinoids tested, with one exception, inhibited the uptake of serotonin at the concentrations used.
Each of the cannabinoids which inhibited [3H]serotonin accumulation did so in a dose-responsive manner.
Molecular pharmacology  •  1976  |  View Paper
Taken together, our study suggests that cannabinoids may have direct and indirect effects on the 5-HT regulatory circuits, resulting in regionally selective changes of 5-HT efflux in the brain.
We showed that the direct effect of cannabinoids caused a reduction in 5-HT efflux whereas the indirect effect resulted in an increase.
ISRN pharmacology  •  2012  |  View Paper