Possible Interaction: Cannabinoids and Rimonabant

“All these … CB1 antagonist rimonabant , suggesting … of CB1 blockade is due not only to the transient suppression of food intake and reduction of lipogenesis but also to an increased … which counteracts the inhibitory effects of ECs, levels of which are increased in fat tissues of obese rodents and humans.”

“Although not affecting most cannabinoid effects in the airways, rimonabant counteracts inhibition of smooth-muscle contraction by cannabinoids in urogenital tissues and may interfere with embryo attachment and outgrowth of blastocysts.”

“The blockade of the cannabinoid system (CB1) by the specific inhibitor ( rimonabant ) decreases food intake and adiposity in animals and in humans.”

“ Rimonabant acts as an antagonist at the cannabinoid-1 (CB-1) receptor which is expressed on adipocytes.”

“ Rimonabant is a selective antagonist of the cannabinoid type 1 (CB1) receptor, part of the endocannabinoid system that plays a significant role in regulating the drive for food ingestion.”

“ Rimonabant is a selective blocker of cannabinoid-1 (CB1) receptors and participates in the regulation of impaired endocannabinoid system.”

“The blockade of the cannabinoid system (CB1) by the specific inhibitor ( rimonabant ) decreases food intake and adiposity in animals and in humans.”

“…,N-(piperidiny-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide ( SR141716A) … cannabinoid (CB) agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-…-2), and behaves as an inverse agonist by producing opposite current effects when applied alone.”

“The cannabinoid inverse agonist rimonabant antagonized the hypothermic effect of all compounds.”

“The CB1 antagonist/inverse agonist AM251 [ N-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide ] blocked these responses.”