Possible Interaction: Cannabinoids and Psychotropic Drugs

“In addition, the use of cannabinoids clinically has been hindered due to pronounced psychoactive side effects.”

“&NA; Cannabinoids are analgesic in man, but their use is limited by their psychoactive properties.”

“Despite the emerging evidence regarding pharmacological activities of cannabinoids , their effective introduction into clinical therapy still remains controversial and strongly limited by their unavoidable psychotropicity.”

“Second, activation or blockade of the endogenous cannabinoid system has been shown to modulate the rewarding effects of non-cannabinoid psychoactive drugs.”

“Importantly, this allows for the avoidance of unwanted psychotropic side effects that accompany exogenously administered cannabinoids.”

“Since the first appearance as psychotropic drugs in illegal markets in 2008, the spread of synthetic cannabinoids is becoming a serious problem in many countries.”

“Like other drugs for neuropathic pain, cannabinoids have a dose titration that is limited by psychoactive side effects.”

“Clinical use of many cannabinoids is limited by their psychotropic effects.”

“The data suggest that CB receptors may have therapeutic potential in migraine, cluster headache, or other primary headaches, although the potential hazards of psychoactive side effects that accompany cannabinoid treatments may be complex to overcome.”

“ Cannabinoids have analgesic and anti‐inflammatory properties but their use is limited by psychotropic activity at CNS receptors.”