Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a year ago

Possible Interaction: Cannabinoids and Norepinephrine

Research Papers that Mention the Interaction

Cannabinoids have been shown to inhibit prostaglandin synthesis, intensify pressor effects of endogenous amines like norepinephrine , and enhance the stimulant effects of amphetamine.
Advances in drug research  •  1977  |  View Paper
In most brain regions, the content of noradrenaline was reduced by cannabinoid drugs (27–66%).
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Since the sympathetic innervation of the human airway smooth muscle is sparse, and mainly the circulating … of beta(2)-adrenoceptor localized on the smooth muscle, it is suggested that inhibition of noradrenaline … cannabinoids , and the subsequent bronchospasm, may be limited to … from sympathetic varicosities is involved in airway relaxation.
European journal of pharmacology  •  2001  |  View Paper
Addition of cannabinoids , such as delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol or the psychoinactive cannabidiol inhibited formation of inositol phosphates evoked by carbachol, glutamate or norepinephrine by 55-90%.
European journal of pharmacology  •  1993  |  View Paper
Moreover, cannabinoid signalling modulates the activity of locus coeruleus noradrenaline neurons and the release of noradrenaline in the medial prefrontal cortex, a brain area that is crucial for fear extinction.
The European journal of neuroscience  •  2021  |  View Paper
As in other areas of the central nervous system, cannabinoids seem to regulate neurotransmission in the retina by inhibiting the release of transmitters such as dopamine, norepinephrine , γ-aminobutyric acid and glutamate.
Neural regeneration research  •  2019  |  View Paper