Possible Interaction: Cannabinoids and Norepinephrine

“ Cannabinoids have been shown to inhibit prostaglandin synthesis, intensify pressor effects of endogenous amines like norepinephrine , and enhance the stimulant effects of amphetamine.”

“In most brain regions, the content of noradrenaline was reduced by cannabinoid drugs (27–66%).”

“Since the sympathetic innervation of the human airway smooth muscle is sparse, and mainly the circulating … of beta(2)-adrenoceptor localized on the smooth muscle, it is suggested that inhibition of noradrenaline … cannabinoids , and the subsequent bronchospasm, may be limited to … from sympathetic varicosities is involved in airway relaxation.”

“Addition of cannabinoids , such as delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol or the psychoinactive cannabidiol inhibited formation of inositol phosphates evoked by carbachol, glutamate or norepinephrine by 55-90%.”

“Moreover, cannabinoid signalling modulates the activity of locus coeruleus noradrenaline neurons and the release of noradrenaline in the medial prefrontal cortex, a brain area that is crucial for fear extinction.”

“As in other areas of the central nervous system, cannabinoids seem to regulate neurotransmission in the retina by inhibiting the release of transmitters such as dopamine, norepinephrine , γ-aminobutyric acid and glutamate.”