Possible Interaction: Cannabinoids and Nitric Oxide

“Based … that synthetic cannabinoids inhibit HIV-1 expression in human microglia … suppress production of inflammatory mediators such as nitric oxide (NO) in human astrocytes, as well as a substantial literature demonstrating neuroprotective properties of cannabinoids … other systems, synthetic cannabinoids have also emerged as potential therapeutic agents in HIV neuropathogenesis.”

“Our results demonstrated that synthetic CBs , by a selective CB1 effect, down-regulate iNOS protein expression and NO production in Abeta-stimulated C6 cells.”

“ Synthetic cannabinoids (CBs), via a selective CB1 receptor activation, negatively modulates both iNOS protein expression and NO production induced by pro-inflammatory stimuli.”

“Finally, although nitric oxide NO ) was shown to exert both pro and anti-apoptotic effects on cardiomyocytes, with an apparently controversial effect on myocardial survival, our data suggest that NO may contribute to the cardioprotective effect of some cannabinoids.”

“ Cannabinoids have been consistently shown to suppress microglia activation and the release of cytotoxic factors including nitric oxide , superoxide and proinflammatory cytokines.”

“It has been reported that different neurotransmitters, such as nitric oxide (NO), are involved in the behavioural effects of cannabinoids.”

“In addition, CB1R and neuronal NOS were coexpressed in cultured cortical neurons, suggesting that cannabinoids might reduce NMDA toxicity by interfering with the generation of NO.”

“Thus, cannabinoids appear to stimulate adult neurogenesis by opposing the antineurogenic effect of NO.”

“However, both NO release and LTP were significantly reduced at higher frequencies (2–4 Hz) of BS train due to cannabinoid receptor‐mediated retrograde inhibition of NO generation at the PF terminals.”

“ Cannabinoids modulate nitric oxide (NO) levels in cells of the central nervous system.”

“This could be attributed to a relationship between cannabinoids and NO.”