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Last Updated: a year ago

Possible Interaction: Cannabinoids and Nitric Oxide

supplement:

Cannabinoids

Research Papers that Mention the Interaction

Based … that synthetic cannabinoids inhibit HIV-1 expression in human microglia … suppress production of inflammatory mediators such as nitric oxide (NO) in human astrocytes, as well as a substantial literature demonstrating neuroprotective properties of cannabinoids … other systems, synthetic cannabinoids have also emerged as potential therapeutic agents in HIV neuropathogenesis.
Journal of Neuroimmune Pharmacology  •  2011  |  View Paper
Our results demonstrated that synthetic CBs , by a selective CB1 effect, down-regulate iNOS protein expression and NO production in Abeta-stimulated C6 cells.
Synthetic cannabinoids (CBs), via a selective CB1 receptor activation, negatively modulates both iNOS protein expression and NO production induced by pro-inflammatory stimuli.
Neuroscience Letters  •  2006  |  View Paper
Finally, although nitric oxide NO ) was shown to exert both pro and anti-apoptotic effects on cardiomyocytes, with an apparently controversial effect on myocardial survival, our data suggest that NO may contribute to the cardioprotective effect of some cannabinoids.
Journal of pharmacological sciences  •  2006  |  View Paper
Cannabinoids have been consistently shown to suppress microglia activation and the release of cytotoxic factors including nitric oxide , superoxide and proinflammatory cytokines.
Prostaglandins & other lipid mediators  •  2013  |  View Paper
It has been reported that different neurotransmitters, such as nitric oxide (NO), are involved in the behavioural effects of cannabinoids.
Clinical and experimental pharmacology & physiology  •  2007  |  View Paper
In addition, CB1R and neuronal NOS were coexpressed in cultured cortical neurons, suggesting that cannabinoids might reduce NMDA toxicity by interfering with the generation of NO.
Molecular Pharmacology  •  2006  |  View Paper
Thus, cannabinoids appear to stimulate adult neurogenesis by opposing the antineurogenic effect of NO.
Journal of Pharmacology and Experimental Therapeutics  •  2006  |  View Paper
However, both NO release and LTP were significantly reduced at higher frequencies (2–4 Hz) of BS train due to cannabinoid receptor‐mediated retrograde inhibition of NO generation at the PF terminals.
The Journal of physiology  •  2005  |  View Paper
Cannabinoids modulate nitric oxide (NO) levels in cells of the central nervous system.
The Journal of Biological Chemistry  •  2002  |  View Paper
This could be attributed to a relationship between cannabinoids and NO.
British journal of pharmacology  •  2001  |  View Paper
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