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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cannabinoids
drug:
Nicotine
Research Papers that Mention the Interaction
“In contrast, adult females demonstrated an opposing effect in which adolescent cannabinoid and nicotine co-exposure resulted in decreased nicotine intake compared to the nicotine only and control groups.”
Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females.“Together, these novel findings demonstrate that adolescent exposure to cannabinoids in the presence or absence of nicotine results in altered affective and reward-related behaviors during adulthood.”
“According to preclinical studies, clinical trials suggest that the manipulation of these systems with cannabinoid or opioid antagonists could be a potential therapeutical strategy for treating nicotine addiction.”
“However, other neurochemical systems also participate in the addictive effects of nicotine including glutamate, cannabinoids , GABA and opioids.”
“Additionally, it appears that interactions of nicotine with the dopamine, serotonin, cannabinoid and probably glutamate systems all contribute to the final perceived stimulus.”
“Interactions of nicotine with caffeine and cannabinoids strengthen proposals that the use of one substance serves as a "gateway" in sequential shifts of the target substance for drug-seeking behaviour, with profound implications for the human use of the substances concerned.”
“ Cannabinoids and endocannabinoids appear to be involved in adding to the rewarding effects of addictive substances, including, nicotine , opiates, alcohol, cocaine, and BDZs.”
“Numerous studies indicate the existence of functional interactions between nicotine and cannabinoids , particularly in relation to anxiety-related processes.”
“Studies have shown that orexin and cannabinoids are likely to play an important role in nicotine dependency.”
“ Cannabinoid type 1 (CB1) receptors control the motivational properties and reinforcing effects of nicotine.”
Nicotine reinforcement is reduced by cannabinoid CB1 receptor blockade in the ventral tegmental area“The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine‐seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists.”
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