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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Cannabinoids and Neuropeptide Y

Research Papers that Mention the Interaction

Peripherally, dual blockade of cannabinoid and NPY pathways has synergistic effects on weight loss, as does combined administration of PYY3–36 and oxyntomodulin in reducing food intake, perhaps due to the recently discovered role of PYY in mediating intestinal Gpr119 activity and controlling glucose tolerance.
Current opinion in endocrinology, diabetes, and obesity  •  2011  |  View Paper
We investigated the interaction of CB1 and NPY in the regulation of energy homeostasis, hypothesizing that dual blockade of CB1 and NPY signalling will induce greater weight and/or fat loss than that induced by single blockade of either system alone.
Diabetes, obesity & metabolism  •  2010  |  View Paper
Combined, these findings demonstrate that cannabinoids augment NPY release in the hypothalamus and that this may be a potential mechanism behind the orexigenic activity of cannabinoids.
Neuropharmacology  •  2005  |  View Paper