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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Cannabinoids and N-Methyl-3,4-Methylenedioxyamphetamine

Research Papers that Mention the Interaction

Behavioral experiments in rodents and in vitro studies investigating the combined effect of MDMA and cannabinoid agents demonstrate modulator effects of acute co-administration on measures like body temperature, conditioned reinforcement, and presumed neurotoxicity.
Current drug abuse reviews  •  2011  |  View Paper
The results suggest that pre-exposure to cannabinoids strengthens the properties of MDMA and favors reinstatement of the craving for the drug, which endorses the gateway hypothesis.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2010  |  View Paper
Finally, the potential neuroprotective action of cannabinoids is not supported by our data; on the contrary, they are evidence of the potential neurotoxic effect of said drugs when administered with MDMA.
On the other hand, WIN 55212-2-induced CPP was reinstated by priming injections … WIN did not reinstate the MDMA-induced CPP.ConclusionsThese results confirm that the cannabinoid system plays a role … effects of MDMA and highlights the risks that sporadic drug … pose in terms of relapse to dependence.
Behavioral and Brain Functions  •  2009  |  View Paper