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Possible Interaction: Cannabinoids and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

Cannabinoids have been demonstrated to modulate several voltage-gated channels (including Ca2+, Na+, and various type of K+ channels), ligand-gated ion channels (i.e., GABA , glycine), and ion-transporting membranes proteins such as transient potential receptor class (TRP) channels.
Advances in pharmacology  •  2017  |  View Paper
The endogenous cannabinoid system , including CB1 receptors, is proposed to play a role in modulating neurotransmission via affecting the release of a variety of neurotransmitters, (e.g. GABA).
Experimental Brain Research  •  2006  |  View Paper
Cannabinoids may attenuate the tonic inhibitory effect of GABA (gamma-aminobuteric acid) neurons in the central pattern generator for swallowing.
PloS one  •  2012  |  View Paper
Taken together, these results show that while the exacerbated GABA release induced by early cannabinoid exposure may be compensated by an increment in GABA(B) receptors, which normally function as inhibitory autoreceptors, adolescent cannabinoid exposure in the females disturbs the normal balance between glutamate and GABA transmission.
Neuropharmacology  •  2012  |  View Paper
Using blockers to isolate inhibitory or excitatory currents, we found that cannabinoids significantly reduced the release probability of both GABA and glutamate, respectively.
Visual Neuroscience  •  2011  |  View Paper
Higher concentrations of cannabinoid inhibit GABA release through mechanisms that are independent of D2 receptor activation.
Journal of Pharmacology and Experimental Therapeutics  •  2009  |  View Paper
Functional studies have shown that activation of cannabinoid CB(1 ) receptors inhibits the synaptic release of many neurotransmitters such as gamma-aminobutyric acid , glutamate, acetylcholine and monoamines.
European journal of pharmacology  •  2008  |  View Paper
It is widely accepted that cannabinoids regulate GABA release by activation of cannabinoid receptor type 1 (CB1).
The Journal of Neuroscience  •  2006  |  View Paper
The effect of these agonists was prevented by the CB1-selective antagonists SR141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-… AM251 [1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide trifluoroacetate salt] (1 μm), indicating that cannabinoids … GABA ….
The Journal of Neuroscience  •  2005  |  View Paper
CB(1) receptor activation increases GABA release in the hypothalamus, a central locus for thermoregulation, suggesting that cannabinoid and GABA systems may be functionally linked in body temperature regulation.
Pharmacology Biochemistry and Behavior  •  2004  |  View Paper
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