Possible Interaction: Cannabinoids and Cocaine

“These preclinical data demonstrate that adolescent cannabinoid exposure reprograms the initial behavioral, molecular, and epigenetic response to cocaine.”

“Based on molecular dynamic simulation, the hydrogen-bonding interaction between cocaine and the GlyR is weakened by cannabinoid docking.”

“BACKGROUND Cannabinoids may have an important therapeutic potential for the treatment of dependence on crack cocaine.”

“A recent study by Xi et al.1 sheds unexpected light on a potential new path toward developing antiaddiction therapies, showing that activation of brain cannabinoid type 2 (CB2) receptors attenuated both the rewarding and the psychomotor-stimulating effects of cocaine.”

“Although the conditions under which cannabinoid drugs have rewarding effects may be more restricted than with other drugs of abuse such as cocaine and heroin, work with these models indicates that cannabinoid reward involves similar brain mechanisms and produces the same kinds of reward‐related behaviour.”

“ Cannabinoids and endocannabinoids appear to be involved in adding to the rewarding effects of addictive substances, including, nicotine, opiates, alcohol, cocaine , and BDZs.”

“This article will review the main papers in the field showing how a modulation of different components of the cannabinoid system might interact with some of the neurobiological/behavioral effects of cocaine related to its reinforcing effects, evaluated in preclinical models or in clinical settings.”

“Human and animal studies indicate that exogenous cannabinoids modulate the acute rewarding effects of cocaine.”

“Likewise, combination of cannabinoids and cocaine might have increase detrimental cardiovascular effects.”

“Adolescent exposure to cannabinoids enhances the behavioural effects of cocaine , and high novelty-seeking trait predicts greater sensitivity to the conditioned place preference (CPP) induced by this drug.”