Possible Interaction: Cannabinoids and Antipsychotic Agents

“Animal studies suggest nicotine and cannabinoids may significantly enhance the therapeutic value of neuroleptics in motor disorders.”

“It appears that the use of nicotine or cannabinoids may greatly improve the clinical response to neuroleptics in motor disorders.”

“Results suggest inflammatory alterations among psychotic individuals with comorbid cannabinoid use.”

“Some limitations of cannabinoid models of psychosis include the relatively high variability in experiences between different individuals, the potential … inducing unwanted effects, such as toxic psychosis in study subjects, and the lack of data showing that effective anti-psychotic treatments can reverse the behavioural … cognitive/motor effects of cannabinoids.”

“This phytocannabinoid shows antioxidant, anti-inflammatory and antipsychotic properties and decreases the acute motor effects of classical antipsychotics.”

“Although evidence points towards an antipsychotic potential for cannabinoid antagonists, experimental studies have shown inconsistent behavioural effects of cannabinoid ligands within and across species.”

“The hypothesis that cannabinoids potentiate the motor effects of neuroleptics and produce their abuse potential by stimulating dopaminergic activity was tested by measuring the ability of THC to increase extracellular dopamine concentrations.”