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Last Updated: a year ago

Possible Interaction: Cannabidiol and Valproic Acid

supplement:

Cannabidiol

Research Papers that Mention the Interaction

Concomitant VPA caused small increases in exposure to CBD metabolites.
Dose adjustments are not likely to be necessary when CBD is combined with STP or VPA.
Epilepsia  •  2020  |  View Paper
If this finding is confirmed, clinicians should perform close monitoring for thrombocytopenia when adding cannabidiol to a regimen that includes valproic acid.
We report a novel and clinically important side effect of thrombocytopenia in one‐third of patients treated concurrently with cannabidiol and valproic acid.
Epilepsia  •  2020  |  View Paper
Cannabidiol can cause liver enzyme elevation, especially when co-administered with valproate.
Pediatric neurology  •  2019  |  View Paper
There was also an increased incidence of aspartate aminotransferase and alanine aminotransferase elevations while taking CBD , with many of the patients with these abnormalities also taking concomitant valproate.
Current Neurology and Neuroscience Reports  •  2018  |  View Paper
Four (15.4%) had changes in antiepileptic drug concentrations and three had elevated aspartate aminotransferase and alanine aminotransferase levels when cannabidiol was administered together with valproate.
CNS Drugs  •  2018  |  View Paper
Six patients taking CBD and valproate developed elevated transaminases; none met criteria for drug-induced liver injury and all recovered.
Neurology  •  2018  |  View Paper
Also, liver function abnormalities were reported during the use of cannabidiol and valproic acid.
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria  •  2020  |  View Paper
Six patients taking CBD and valproate developed elevated transaminases; none met criteria for drug-induced liver injury and all recovered.
Epilepsy currents  •  2019  |  View Paper