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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cannabidiol
drug:
Valproic Acid
Research Papers that Mention the Interaction
“Concomitant VPA caused small increases in exposure to CBD metabolites.”
“Dose adjustments are not likely to be necessary when CBD is combined with STP or VPA.”
Clinical implications of trials investigating drug‐drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs“If this finding is confirmed, clinicians should perform close monitoring for thrombocytopenia when adding cannabidiol to a regimen that includes valproic acid.”
“We report a novel and clinically important side effect of thrombocytopenia in one‐third of patients treated concurrently with cannabidiol and valproic acid.”
“ Cannabidiol can cause liver enzyme elevation, especially when co-administered with valproate.”
“There was also an increased incidence of aspartate aminotransferase and alanine aminotransferase elevations while taking CBD , with many of the patients with these abnormalities also taking concomitant valproate.”
“Four (15.4%) had changes in antiepileptic drug concentrations and three had elevated aspartate aminotransferase and alanine aminotransferase levels when cannabidiol was administered together with valproate.”
“Six patients taking CBD and valproate developed elevated transaminases; none met criteria for drug-induced liver injury and all recovered.”
“Also, liver function abnormalities were reported during the use of cannabidiol and valproic acid.”
Clinical pharmacology of cannabidiol in refractory epilepsy.“Six patients taking CBD and valproate developed elevated transaminases; none met criteria for drug-induced liver injury and all recovered.”
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