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Last Updated: a year ago

Possible Interaction: Cannabidiol and Topiramate

supplement:

Cannabidiol

Research Papers that Mention the Interaction

OBJECTIVE We have previously shown that cannabidiol (CBD; Epidiolex®) significantly affects levels of clobazam/N-desmethylclobazam, rufinamide, topiramate , zonisamide, and eslicarbazepine.
Epilepsy & Behavior  •  2019  |  View Paper
There is potential for pharmacokinetic interactions between CBD and brivaracetam, clobazam, eslicarbazepine, lacosamide, gabapentin, oxcarbazepine, phenobarbital, potassium bromide, pregabalin, rufinamide, sirolimus/everolimus, stiripentol, tiagabine, topiramate and zonisamide.
Seizure  •  2021  |  View Paper
We showed that cannabidiol increased the activity of topiramate , oxcarbazepine, pregabalin, tiagabine, and gabapentin.
Neuropharmacology  •  2019  |  View Paper
Cannabidiol, topiramate , and rufinamide were more likely to result in dropouts; moreover, a significantly greater percentage of patients receiving cannabidiol experienced premature discontinuation as compared to placebo, clobazam, and lamotrigine.
Developmental medicine and child neurology  •  2021  |  View Paper