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Last Updated: a year ago

Possible Interaction: Cannabidiol and Tetrahydrocannabinol (THC)

Research Papers that Mention the Interaction

Cannabidiol ( CBD), another important constituent, is able to modulate the distinct unwanted psychotropic effect of THC.
Planta medica  •  2012  |  View Paper
CBD has been known to abolish many of the psychotropic effects of Delta9-THC , but, unexpectedly, failed to demonstrate a reversal of Delta9-THC-induced P300 reduction.
European Neuropsychopharmacology  •  2008  |  View Paper
The additional determination of these compounds is interesting from forensic and medical points of view because it can be used for further proof of cannabis exposure and because CBD is known to modify the effects of THC.
Journal of analytical toxicology  •  2005  |  View Paper
Fifteen milligrams THC would appear to be sedative, while 15 mg CBD appears to have alerting properties as it increased awake activity during sleep and counteracted the residual sedative activity of 15 mg THC.
Journal of clinical psychopharmacology  •  2004  |  View Paper
CBD significantly attenuated the subjective euphoria of THC.
Clinical pharmacology and therapeutics  •  1976  |  View Paper
Abstract Based on previous observations that cannabidiol (CBD) blocks some effects of Δ9-tetrahydrocannabinol (Δ9-THC ) in laboratory animals, the present work was carried out to study possible interaction between CBD and Δ9-THC in human beings.
CBD also decreased the anxiety component of Δ9-THC effects, in such a way that the subjects reported more pleasurable effects.
On the other hand, CBD was efficient in blocking most of the effects of Δ9-THC when both drugs were given together.
European journal of pharmacology  •  1974  |  View Paper
Moreover, it has been found that coadministration of CBD and Δ9-THC , followed by radiation therapy, causes an increase of autophagy and apoptosis in cancer cells.
BioMed research international  •  2018  |  View Paper
Studies conflict as to whether CBD attenuates or exacerbates the behavioral and cognitive effects of THC.
Neuropsychopharmacology  •  2018  |  View Paper
Results from some of these studies have fostered the view that CBD and THCV modulate the effects of THC via direct blockade of cannabinoid CB1 receptors, thus behaving like first‐generation CB1 receptor inverse agonists, such as rimonabant.
British journal of pharmacology  •  2015  |  View Paper
Δ9-Tetrahydrocannabinol in cannabis can cause symptoms of schizophrenia when acutely administered, and cannabidiol (CBD), another compound in cannabis, can counter many of these effects.
Neurotherapeutics  •  2015  |  View Paper
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