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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cannabidiol
drug:
Temozolomide
Research Papers that Mention the Interaction
“Previous observations from our group demonstrated that … administration of THC (or of THC + CBD at a 1:1 ratio, a mixture that resembles the … of the cannabinoid‐based medicine Sativex®) in combination with Temozolomide , the benchmark agent for the treatment of GBM, synergistically reduces the growth of glioma xenografts.”
Optimization of a preclinical therapy of cannabinoids in combination with temozolomide against glioma“We also found that the administration of THC (or of THC + CBD at a 1:1 ratio) in combination with temozolomide (TMZ), the benchmark agent for the treatment of GBM, synergistically reduces the growth of glioma xenografts.”
“Lastly, CBD and temozolomide combination therapy in patient-derived neurosphere cultures and mouse orthotopic models showed significant synergistic effect in both controlling tumor size and improving survival.”
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
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