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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Cannabidiol
drug:
Tamoxifen
Research Papers that Mention the Interaction
“In the present study we have demonstrated a synergistic cytotoxic effect of TAM and CBD against T-ALL cells.”
Tamoxifen Sensitizes Acute Lymphoblastic Leukemia Cells to Cannabidiol by Targeting Cyclophilin-D and Altering Mitochondrial Ca2+ Homeostasis“It was postulated that CBD may diminish tamoxifen metabolism by CYP3A4 and 2D6 to form active metabolite endoxifen, which exerts the anticancer benefits.”
“Patients receiving CBD and interacting chemotherapeutic drugs, such as tamoxifen , require monitoring to identify possible subtherapeutic response to treatment.”
Reduction in Tamoxifen Metabolites Endoxifen and N-desmethyltamoxifen With Chronic Administration of Low Dose Cannabidiol: A CYP3A4 and CYP2D6 Drug Interaction.
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