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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Cannabidiol and Sertraline



Research Papers that Mention the Interaction

Gene expression analyses revealed a long-term increase of corticotropin releasing factor (Crf) that was significantly normalized with the combination CBD plus STR.
Interestingly, CBD and STR alone or combined induced a significant and marked increase of Slc6a4 gene expression.
These results point out … action of the combination CBD … STR to enhance fear extinction and reduce anxiety-like behaviors, normalizing gene expression alterations in this animal model of PTSD and … that the combination of CBD with STR deserves to be further explored for the treatment of patients with PTSD.
Treatment with CBD improved these behaviors in PTSD animals, effects that were significantly potentiated when combined with STR.
Frontiers in Pharmacology  •  2021  |  View Paper
In PK models, CBD and/or THC increases sertraline and es/citalopram concentrations in adolescents, and coadministration of CBD and CYP2C19-metabolized SSRIs increases the risk of cough, diarrhea, dizziness, and fatigue.
Journal of personalized medicine  •  2021  |  View Paper