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Last Updated: a year ago

Possible Interaction: Cannabidiol and Serotonin

supplement:

Cannabidiol

Research Papers that Mention the Interaction

CBD has been shown to modulate a wide variety of targets including the cannabinoid receptors, orphan GPCRs such as GPR55 and GPR18, serotonin , adenosine, and opioid receptors as well as ligand-gated ion channels among others.
Advances in experimental medicine and biology  •  2021  |  View Paper
Thus, we concluded that chronic administration of CBD (100 mg/kg) induced antidepressant-like effects by increasing 5-HT and NA levels in the HPC.
Neuroscience Letters  •  2021  |  View Paper
increasing doses of CBD (0.1-1.0 mg/kg) decreased the firing rate of 5-HT neurons in the dorsal raphe nucleus, which was prevented by administration of the 5-HT1A antagonist WAY 100635 (0.3 mg/kg, i.v.)
Pain  •  2019  |  View Paper
Moreover, experimental evidence has shown that injections of CBD enhance wake-related compounds, such as monoamines (dopamine, serotonin , epinephrine, and norepinephrine).
Neurochemical Research  •  2018  |  View Paper
In vivo microdialysis revealed that the administration of CBD significantly enhanced serotonin and glutamate levels in vmPFCx in a different manner depending on the emotional state and the duration of the treatment.
Neuropharmacology  •  2016  |  View Paper
Also, we verified, … microdialysis, if CBD … serotonin (5-HT) release and, by quantitative polymerase chain reaction, if there are changes in 5HT-1A or 5HT-2C mRNA expression … results showed that repeated but not acute peripheral administration of CBD decreases escape responses in the ETM, suggesting a panicolytic effect.
Psychopharmacology  •  2012  |  View Paper
CBD reversibly inhibited 5-HT (1 μM)-evoked currents in a concentration-dependent manner (IC50 = 0.6 μM).
Journal of Pharmacology and Experimental Therapeutics  •  2010  |  View Paper
Acute CBD inhibits excess 5-HT release from DRN to amygdala and releases anandamide (AEA) onto amygdala inputs.
IBRO neuroscience reports  •  2021  |  View Paper
The same compounds also reduced hypothalamic NE synthesis and DA release, whereas the sole CBD inhibited 5-HT synthesis.
Antioxidants  •  2020  |  View Paper
It is proposed that CBD enhances non-NMDA LTP in the slice by facilitating release of serotonin from terminals, consequently ameliorating the detrimental effects of pilocarpine.
Serotonin , possibly acting at a 5HT1A receptor, or fenfluramine (FFA), which causes release of serotonin from its native terminals, mimicked the effect of CBD.
Front. Mol. Neurosci.  •  2018  |  View Paper