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“Topical application of CBD to the skin of control rats significantly upregulated plasma ether-linked phosphatidylethanolamines ( PEo ) and ceramides.”
International journal of molecular sciences • 2021 | View Paper
“In conclusion, up-regulation of PS may suggest that CBD inhibits their oxidative modification, while changes in the content of PE and SM may indicate a role of CBD in promoting autophagy and improving the status of the transepidermal barrier.”
“Increases in NAEs observed after CBD treatment had previously been attributed to FAAH inhibition; however, data here suggest the alternative hypothesis that CBD is activating NAPE-PLD to increase NAE levels.”