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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Cannabidiol and Phenobarbital

supplement:

Cannabidiol

Research Papers that Mention the Interaction

There is potential for pharmacokinetic interactions between CBD and brivaracetam, clobazam, eslicarbazepine, lacosamide, gabapentin, oxcarbazepine, phenobarbital , potassium bromide, pregabalin, rufinamide, sirolimus/everolimus, stiripentol, tiagabine, topiramate and zonisamide.
Seizure  •  2021  |  View Paper
The combination of phenobarbital and cannabidiol reduced the expression of SE of group B. The mortality rate of groups A and B at the end of the crossover protocol was 30% and 9%, respectively (p=0.2).
Seizure  •  2021  |  View Paper
CBD (50 mg kg-l) was much less active and whilst it significantly reduced the ED50 of phenobarbitone when assessed as protection from convulsions, it produced no significant change when effectiveness was assessed by the duration of hind limb extension.
The Journal of pharmacy and pharmacology  •  1975  |  View Paper