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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cannabidiol
drug:
Phenobarbital
Research Papers that Mention the Interaction
“There is potential for pharmacokinetic interactions between CBD and brivaracetam, clobazam, eslicarbazepine, lacosamide, gabapentin, oxcarbazepine, phenobarbital , potassium bromide, pregabalin, rufinamide, sirolimus/everolimus, stiripentol, tiagabine, topiramate and zonisamide.”
Interaction of cannabidiol with other antiseizure medications: A narrative review“The combination of phenobarbital and cannabidiol reduced the expression of SE of group B. The mortality rate of groups A and B at the end of the crossover protocol was 30% and 9%, respectively (p=0.2).”
Cannabidiol modifies the seizure expression and effects of antiseizure drugs in a rat model of recurrent severe seizures“ CBD (50 mg kg-l) was much less active and whilst it significantly reduced the ED50 of phenobarbitone when assessed as protection from convulsions, it produced no significant change when effectiveness was assessed by the duration of hind limb extension.”
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