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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cannabidiol
drug:
Pentobarbital
Research Papers that Mention the Interaction
“THC, CBN and CBD added to normal rat liver microsomes in vitro inhibited pentobarbital metabolism competitively, CBD being a much more potent inhibitor than THC and CBN.”
Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat.“ConclusionsThese results suggest that binding of ∆9-THC to the CB1 receptor is involved in the synergism with pentobarbital, and that potentiating effect of CBD with pentobarbital may differ from that of ∆9-THC.”
∆9-Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB1 receptor
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