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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Cannabidiol
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“ Cannabidiol significantly reduced the elevations of serum creatine kinase-MB and troponin T, and cardiac malondialdehyde, tumor necrosis factor-α, nitric oxide and calcium ion levels, and attenuated the decreases in cardiac reduced glutathione, selenium and zinc ions.”
Cardioprotective effect of cannabidiol in rats exposed to doxorubicin toxicity.“Moreover, under the same experimental conditions, CBD impaired iNOS and IL-1beta protein expression, and the related NO and IL-1beta release.”
“There were decreases in PGE2 plasma levels, tissue COX activity, production of oxygen-derived free radicals, and NO after three doses of cannabidiol.”
“Extensive basic laboratory work also shows that CBD modulates inflammation through multiple interrelated mechanisms including impaired release of inflammatory cytokines such as interleukin 6 and tumor necrosis factor α, decreased nitric oxide ”
Development of Raynaud Phenomenon Following Use of Medical Cannabis.“Treatment with 1 microM CBD inhibited ROS formation and p38 MAPK activation, NO and TNF-alpha formation, and maintained cell morphology.”
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