Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a year ago

Possible Interaction: Cannabidiol and Nitric Oxide

supplement:

Cannabidiol

Research Papers that Mention the Interaction

Cannabidiol significantly reduced the elevations of serum creatine kinase-MB and troponin T, and cardiac malondialdehyde, tumor necrosis factor-α, nitric oxide and calcium ion levels, and attenuated the decreases in cardiac reduced glutathione, selenium and zinc ions.
Environmental toxicology and pharmacology  •  2013  |  View Paper
Moreover, under the same experimental conditions, CBD impaired iNOS and IL-1beta protein expression, and the related NO and IL-1beta release.
British journal of pharmacology  •  2007  |  View Paper
There were decreases in PGE2 plasma levels, tissue COX activity, production of oxygen-derived free radicals, and NO after three doses of cannabidiol.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Extensive basic laboratory work also shows that CBD modulates inflammation through multiple interrelated mechanisms including impaired release of inflammatory cytokines such as interleukin 6 and tumor necrosis factor α, decreased nitric oxide
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases  •  2020  |  View Paper
Treatment with 1 microM CBD inhibited ROS formation and p38 MAPK activation, NO and TNF-alpha formation, and maintained cell morphology.
Molecular vision  •  2008  |  View Paper