Possible Interaction: Cannabidiol and Methamphetamine

“ CBD also potentiated the extinction of cocaine- and amphetamine-induced conditioned place preference (CPP), impaired the reconsolidation of cocaine CPP and prevented priming-induced reinstatement of METH CPP.”

“Some studies have proposed that cannabidiol (CBD) decreases the motivation for METH seeking, but reports indicate that the therapeutic benefits are only for heroin.”

“The current research disclosed that CBD inhibited the rewarding characteristic of METH via D1-like dopamine receptors in the CA1 region of the hippocampus.”

“These novel findings suggest that the chronic administration of METH induces memory impairment and presents interesting implications for the potential use of CBD in treating impairment deficits after chronic exposure to psychostimulant drugs such as METH.”

“A previous research in our laboratory has demonstrated that CBD prevents reinstatement of METH even in 24‐hour rapid eye movement (REM) sleep‐deprived (RSD) rats.”

“Conclusion: This is the first demonstration that cannabidiol can reduce the motivation to seek and consume methamphetamine , and suggests that cannabidiol might be worth trialing as a novel pharmacotherapy for methamphetamine dependence.”

“ Cannabidiol (CBD) has been shown to reduce the effects of METH through different mechanisms such as increasing the ECS activity, regulating emotional memory in the ventral hippocampus through D2-like dopamine receptors, and decreasing the mesolimbic dopaminergic activity.”