Possible Interaction: Cannabidiol and Marijuana

“Compared with placebo, cannabidiol 400 mg decreased THC-COOH:creatinine ratio by -94·21 ng/mL (95% interval estimate -161·83 to -35·56) and increased abstinence from cannabis by 0·48 days per week (0·15 to 0·82).”

“Compared with placebo, cannabidiol 800 mg decreased THC-COOH:creatinine ratio by -72·02 ng/mL (-135·47 to -19·52) and increased abstinence from cannabis by 0·27 days per week (-0·09 to 0·64).”

“It is quite possible that cannabidiol , licensed in the USA for treating rare genetic epilepsies, may open the door for the widespread legalisation of recreational cannabis.”

“ CBD may have therapeutic potential for the treatment of psychosis following cannabis use , as well as schizophrenia, possibly with better tolerability than current antipsychotic treatments.”

“The high degree of interindividual variability in the responses to cannabis is contributed by a wide spectrum of factors, including genetic and environmental determinants, as well as differences in the relative concentrations of THC and other alkaloids (such as cannabidiol ) within the plant itself.”

“ Marijuana and its constitutive cannabinoids--tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD)--markedly affect mammalian cells.”

“Abstract Background: Ratios of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) impact metabolism and therapeutic effects of cannabis.”

“RESULTS Depression, anxiety and cognition significantly worsened as the reported percentage of CB , T HC and overall frequency of can nabis use in the past 30 days increased.”

“Frequent cannabis users may show a blunted anti- psychotic response to CBD , which is of concern due to the high rates of cannabis use disorders in patients with schizophrenia.”

“ Cannabidiol (CBD) is not psychoactive but plays a modulating role on cannabis psychoactive effects.”

“Finally, cannabis smoke contains various cannabinoids, for example cannabidiol which also have anti-inflammatory and antifibrotic properties, with the unconfirmed hypothesis that these properties can partially modulate the deleterious action of cannabis smoke.”