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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Cannabidiol and Hexobarbital

supplement:

Cannabidiol

Research Papers that Mention the Interaction

CBD did not alter the kinetics of THC, but it decreased metabolism of hexobarbital.
NIDA research monograph  •  1986  |  View Paper
Cannabidiol ( CBD), 600 mg/day orally for 5 to 12 days, inhibited hexobarbital metabolism in ten subjects.
In four subjects who received intravenous and oral hexobarbital , systemic clearance was 36% lower while bioavailability was 10% greater during CBD.
Clinical pharmacology and therapeutics  •  1980  |  View Paper
The effect of CBD can be explained by an inhibition of the hexobarbital metabolism.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
4 Acute CBD treatment increased the half‐time of hexobarbitone in the brain, which returned toward normal with the development of tolerance.
British journal of pharmacology  •  1979  |  View Paper