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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Cannabidiol
drug:
Hexobarbital
Research Papers that Mention the Interaction
“ CBD did not alter the kinetics of THC, but it decreased metabolism of hexobarbital.”
Interactions of cannabis with other drugs in man.“ Cannabidiol ( CBD), 600 mg/day orally for 5 to 12 days, inhibited hexobarbital metabolism in ten subjects.”
“In four subjects who received intravenous and oral hexobarbital , systemic clearance was 36% lower while bioavailability was 10% greater during CBD.”
“The effect of CBD can be explained by an inhibition of the hexobarbital metabolism.”
Cannabinoids and hexobarbital induced loss of righting reflexes“4 Acute CBD treatment increased the half‐time of hexobarbitone in the brain, which returned toward normal with the development of tolerance.”
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