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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cannabidiol
drug:
Haloperidol
Research Papers that Mention the Interaction
“Conclusions: We confirmed that CBD can ameliorate motor impairments produced by haloperidol.”
“Our data suggest that CBD can be combined with haloperidol to prevent the emergent of extrapyramidal side effects and long-term movement disorders, such as acute dystonic disorder and TD.”
“Results: This study found that CBD co-administration with haloperidol attenuated the VCMs and increased motor tone produced by haloperidol.”
Investigation of the effects of cannabidiol on vacuous chewing movements, locomotion, oxidative stress and blood glucose in rats treated with oral haloperidol“Daily CBD administration before each haloperidol injection prevented this effect.”
“The combination of CBD and haloperidol also increased PGC-1α mRNA expression, a co-activator of PPARγ receptors.”
“The present study investigated if CBD would attenuate orofacial dyskinesia, oxidative stress and inflammatory changes induced by chronic administration of haloperidol in mice.”
“To further investigate this latter effect, we tested whether CBD (15-60mg/kg) would attenuate the catalepsy and c-Fos protein expression in the dorsal striatum induced by haloperidol (0.6mg/kg).”
“ CBD (60 mg/kg/daily) administered in the last 7 days of haloperidol treatment attenuated both behavioral effects.”
PPARγ receptors are involved in the effects of cannabidiol on orofacial dyskinesia and cognitive dysfunction induced by typical antipsychotic in mice
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