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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Cannabidiol and Escitalopram

supplement:

Cannabidiol

Research Papers that Mention the Interaction

However, CBD significantly inhibited CYP3A4 and CYP2C19-mediated metabolism of citalopram and its stereoisomer escitalopram at physiologically relevant concentrations, suggesting a possible in vivo DDI.
In patients on citalopram or escitalopram , the addition of CBD significantly increased citalopram plasma concentrations, although it was uncertain whether this also increased selective serotonin reuptake inhibitor–mediated adverse events.
Journal of clinical psychopharmacology  •  2021  |  View Paper