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Last Updated: 3 years ago

Possible Interaction: Cannabidiol and Erythromycin

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supplement:

Cannabidiol

drug:

Erythromycin

Research Papers that Mention the Interaction

“ CBD treatment (120 mg/kg) inhibited more than 75% of hepatic 6 beta-testosterone hydroxylase and erythromycin N-demethylase activities (functional markers of P-450IIIA) after 2 hr.”

“On the other hand, erythromycin N-demethylase activity increased 4-fold after phenobarbital pretreatment and, as in untreated animals, was comparably inhibited by CBD , demonstrating its susceptibility to this drug.”

Selective inactivation of mouse liver cytochrome P-450IIIA by cannabidiol.

Molecular pharmacology • 1990 | View Paper

“However, after such repeated treatments a fresh dose of CBD can once again inactivate erythromycin N-demethylase activity but not hexobarbital hydroxylase activity.”

Effect of cannabidiol on cytochrome P-450 isozymes.

Biochemical pharmacology • 1989 | View Paper

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