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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cannabidiol
drug:
Cyclosporine
Research Papers that Mention the Interaction
“ Cannabidiol has the potential to clinically affect cyclosporine metabolism which may result in increased cyclosporine blood levels and an increase in its toxic side effects, and likewise may also affect tetrahydrocannabinol and its metabolite levels in man.”
Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes.“In addition, an inhibitor of the mitochondrial permeability transition pore, cyclosporin A , also blocked the effects of CBD on cell viability and IL-8 production.”
“Dissipation of the ∆Ψm by cannabidiol was prevented by cyclosporine A and reverted by Ru360, inhibitors of the permeation transition pore and mitochondrial Ca2+ uniporter, respectively.”
“Furthermore, CsA prevented cardiolipin oxidation and the MPTP opening induced by CBD.”
“The inhibition or desensitization by CBD was reversed in the presence of forskolin and cyclosporin.”
CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons“Increased CyA concentration has been reported in patients with grapefruit juice, chamomile, or berberine, and with cannabidiol or resveratrol in animal studies.”
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