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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cannabidiol
supplement:
Cocaine
Research Papers that Mention the Interaction
“ CBD promotes alteration in contextual memory associated with cocaine and in the neuroadaptations, hepatotoxicity and seizures induced by cocaine.”
“ CBD promotes reduction on cocaine self-administration.”
Evaluation of the potential use of cannabidiol in the treatment of cocaine use disorder: A systematic review“ CBD also potentiated the extinction of cocaine- and amphetamine-induced conditioned place preference (CPP), impaired the reconsolidation of cocaine CPP and prevented priming-induced reinstatement of METH CPP.”
“ CBD has reversed toxicity and seizures induced by cocaine , behavioural sensitization induced by amphetamines, motivation to self-administer cocaine and METH, context- and stress-induced reinstatement of cocaine and priming-induced reinstatement of METH seeking behaviours.”
“Since co-abuse of opiates and cocaine with alcohol is common, the reported anti-reinstatement actions of CBD across three major classes of abused drugs further add to the putative treatment drug promise of this phytocannabinoid.”
“ CBD also reduced consolidation of cocaine memory , and this was evident 1 day after cessation of CBD treatment.”
Cannabidiol (CBD) reduces cocaine-environment memory in mice“ CBD inhibited cocaine self-administration maintained by low, but not high, doses of cocaine.”
“Systemic administration (10-40 mg/kg) of CBD dose-dependently inhibited cocaine self-administration, shifted cocaine dose-response curve downward, and lowered break-point for cocaine self-administration under a progressive-ratio schedule of reinforcement.”
“These findings suggest that CBD may have certain therapeutic utility by blunting the acute rewarding effects of cocaine via a DA-dependent mechanism.”
“ Cannabidiol (20 mg/kg) reduced cocaine self‐administration behaviour acquisition and total cocaine intake and enhanced adult hippocampal neurogenesis.”
“ CBD reduced cocaine voluntary consumption and progressive ratio breaking point in the self‐administration paradigm, but not drug‐induced reinstatement.”
“We found that CBD impaired the reconsolidation of preference for the environment previously paired with both morphine and cocaine.”
“Using confocal liver intravital microscopy, we observed that CBD (30 mg/kg) reduced acute liver inflammation and damage induced by cocaine and prevented associated seizure.”
“ CBD (30 mg/kg) pre-treatment increased the latency and reduced the duration of cocaine (75 mg/kg)-induced seizures in mice.”
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