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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Cannabidiol and Citalopram

supplement:

Cannabidiol

Research Papers that Mention the Interaction

However, CBD significantly inhibited CYP3A4 and CYP2C19-mediated metabolism of citalopram and its stereoisomer escitalopram at physiologically relevant concentrations, suggesting a possible in vivo DDI.
In patients on citalopram or escitalopram, the addition of CBD significantly increased citalopram plasma concentrations, although it was uncertain whether this also increased selective serotonin reuptake inhibitor–mediated adverse events.
Journal of clinical psychopharmacology  •  2021  |  View Paper