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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cannabidiol
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ CBD responses were prevented by removal of bath calcium , ruthenium red, and the TRPA1 antagonist A967079; but not the TRPV1 antagonist SB366791; suggesting an essential role for TRPA1.”
Cannabidiol activation of vagal afferent neurons requires TRPA1.“When tested individually AEA, CBD or NAGly inhibited SOCE.”
“Both THC and cannabidiol inhibited depolarization-dependent uptake of calcium without affecting the resting uptake (Table I).”
“ CBD also increased mitochondrial concentrations of reactive oxygen species (ROS) (160 ± 53 ….8%, 20 µM CBD vs. control, respectively, p < 0.001) and Ca2+ (187 ± 78 vs. 105 ± 10%, 20 µM CBD vs. the control, respectively, p < … was associated with a significantly decreased mitochondrial branch length and increased fission.”
Cannabidiol Modulates Mitochondrial Redox and Dynamics in MCF7 Cancer Cells: A Study Using Fluorescence Lifetime Imaging Microscopy of NAD(P)H“Furthermore, CBD caused a marked increase in ability to generate LTP, an effect that was blocked by calcium store antagonists as well as by a reduction in serotonin tone.”
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