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“We could conclude that decreased mucoadhesion strength of polycarbophil in the presence of calcium is due to the chelation of polycarbophil carboxylic groups by calcium and crosslinking of polymer.”
International journal of pharmaceutics • 2002 | View Paper
“As a consequence extracellular calcium binds to polycarbophil in lower extent if compared with polycarbophil dispersion without calcium and transport is increased to a lesser degree.”