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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Calcium Supplement
drug:
Gentamicin
Research Papers that Mention the Interaction
“ Dietary calcium loading reduces gentamicin nephrotoxicity in rats.”
Modification of experimental gentamicin nephrotoxicity by selective parathyroidectomy.“With administration of intermediate concentrations of 40 or 50 mM GM, calcium increased variably in different cells, returning to baseline in some cases, or rising continuously in others.”
“It was found that calcium has a strong antagonistic effect on gentamicin activity, particularly with regard to P. aeruginosa.”
“Physiologic concentrations of calcium in serum antagonize the activities in vitro of gentamicin and tobramycin on Pseudomonas aeruginosa.”
“Physiological concentrations of calcium in serum antagonize the activities of colistin, polymyxin B, and gentamicin against Pseudomonas aeruginosa.”
“It is concluded that oral supplementation of calcium during treatment with GM resulted in significant reduction of morphological and functional kidney alterations.”
Beneficial Effects of Calcium Oral Coadministration in Gentamicin-Induced Nephrotoxicity in Rats“Background: Gentamicin , a well-known nephrotoxic drug, affects calcium and magnesium homeostasis.”
“Neostigmine and calcium antagonized the neuromuscular blockade caused by gentamicin , but augmented that caused by clindamycin.”
“ Calcium loading counteracts gentamicin reducing effect on plasma testosterone levels.”
“It is proposed that the depressant action of GM on is was due to a blockade of slow channels, whereby GM may have dislocated Ca from the binding sites at slow channels on the external surface of the membrane.”
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