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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Calcium Supplement
drug:
Etelcalcetide
Research Papers that Mention the Interaction
“ Etelcalcetide … Ca concentration in HEK‐293T cells expressing human Ca‐sensing receptor with an EC50 value (95% confidence interval) of 0.53 &mgr;M (0.28–… PTH secretion from rat parathyroid gland cells with 0.36 &mgr;M (0.24–0.54 &mgr;M) by activating Ca‐sensing receptor.”
Pharmacology of Parsabiv® (etelcalcetide, ONO‐5163/AMG 416), a novel allosteric modulator of the calcium‐sensing receptor, for secondary hyperparathyroidism in hemodialysis patients“ Etelcalcetide , a recently approved intravenous calcimimetic, reduces serum parathyroid hormone (PTH), calcium , phosphorus, and fibroblast growth factor-23 concentrations.”
“ Etelcalcetide is an intravenous calcimimetic that increases sensitivity of the calcium-sensing receptor to calcium and decreases PTH secretion.”
“Additionally, etelcalcetide , which appears to reduce calcium substantially more than cinacalcet does, can prolong the QTc electrocardiographic interval.”
“ Etelcalcetide reduces circulating levels of parathyroid hormone and calcium by binding directly to the calcium-sensing receptor.”
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