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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Calcium Phosphate
drug:
Zonisamide
Research Papers that Mention the Interaction
“TPM and zonisamide ZNS ) mainly increase the risk of calcium phosphate and not calcium oxalate, which is mentioned by Jion et al. Indeed, most clinicians are unaware of TPM-associated nephrolithiasis.”
Topiramate and Nephrolithiasis: A Comment“The supposed mechanism is that zonisamide induces urine alkalinization and then promotes crystallization of urine components such as calcium phosphate by inhibition of carbonate dehydratase in renal tubular epithelial cells.”
Silicate Urolithiasis during Long-Term Treatment with Zonisamide
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