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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Calcium Phosphate and Zonisamide

Research Papers that Mention the Interaction

TPM and zonisamide ZNS ) mainly increase the risk of calcium phosphate and not calcium oxalate, which is mentioned by Jion et al. Indeed, most clinicians are unaware of TPM-associated nephrolithiasis.
Headache  •  2015  |  View Paper
The supposed mechanism is that zonisamide induces urine alkalinization and then promotes crystallization of urine components such as calcium phosphate by inhibition of carbonate dehydratase in renal tubular epithelial cells.
Case reports in medicine  •  2013  |  View Paper