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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Calcium Phosphate
drug:
Alendronate
Research Papers that Mention the Interaction
“This study showed that a high dose of ALN strongly reduced osteoclastic resorption of β-TCP induced by rhBMP-2, resulting in decreased bone formation.”
Local application of alendronate controls bone formation and β-tricalcium phosphate resorption induced by recombinant human bone morphogenetic protein-2.“Treatment of animals with ALN caused a decrease in βTCP turnover.”
Bisphosphonates reduce biomaterial turnover in healing of critical-size rat femoral defects“Initially, the diagrams seem to show a tendency that alendronate improves the known properties of calcium phosphate as a bone graft substitute.”
“ Alendronate decreased the number of TRAP-positive cells attached to β-TCP , the numbers of ED1-positive multinucleated giant cells, and resorption of β-TCP.”
“ Alendronate may help to reduce insufficiency of newly formed bone after implantation of β-TCP in diseases characterized by increased bone resorption such as rheumatoid arthritis.”
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