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Last Updated: 3 months ago

Possible Interaction: Calcium Phosphate and Alendronate

Research Papers that Mention the Interaction

The results of the structural, spectroscopic, and microscopic investigation show that soaking OCP into alendronate solutions provoked the deposition of long crystalline rod-shaped formations, most likely a calcium alendronate complex, onto the calcium phosphate.
Bone  •  2012  |  View Paper
Aln caused a marked decrease in calcium oxalate and calcium hydrogen phosphate supersaturation.
Aln caused a marked decrease in calcium oxalate and calcium hydrogen phosphate supersaturation.
Kidney international  •  1999  |  View Paper
Treatment of animals with ALN caused a decrease in βTCP turnover.
Journal of orthopaedic surgery  •  2018  |  View Paper
Initially, the diagrams seem to show a tendency that alendronate improves the known properties of calcium phosphate as a bone graft substitute.
Journal of Orthopaedic Surgery and Research  •  2015  |  View Paper
Alendronate decreased the number of TRAP-positive cells attached to β-TCP , the numbers of ED1-positive multinucleated giant cells, and resorption of β-TCP.
Alendronate may help to reduce insufficiency of newly formed bone after implantation of β-TCP in diseases characterized by increased bone resorption such as rheumatoid arthritis.
Journal of Bone and Mineral Metabolism  •  2012  |  View Paper
The results show that local application of ALN at a concentration of 10(-2) to 10(-6)M reduced the number of osteoclasts on the surface of beta-TCP.
Journal of biomedical materials research. Part A  •  2009  |  View Paper