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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Calcium Glucarate and Isotretinoin

Research Papers that Mention the Interaction

Dietary calcium glucarate (CGT) increased the activity of non-toxic levels of dietary isotretinoin against pre-established tumors in the chemically-induced rat mammary tumour model.
In contrast, the combination of 1.0 mmol/kg of isotretinoin and 64 mmol/kg of CGT caused a reversible inhibition of tumour growth, culminating in a net decrease in tumour volume of 20%.
European journal of cancer  •  1992  |  View Paper
Furthermore, ineffective sub-optimal dosages of glucarate and 13-cis-retinoic acid interacted synergistically to inhibit the growth in vitro of the MCF-7 human breast cancer cells.
Biochemical and biophysical research communications  •  1989  |  View Paper