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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Calcium Glucarate and Fenretinide

Research Papers that Mention the Interaction

The apparent higher efficacy of HPR in combination with glucarate (GT) compared to the single agents could be due to increased net formation of HPR glucuronide conjugate following conversion of GT to the beta-glucuronidase inhibitor, D-glucaro-1,4-lactone.
Biochemical pharmacology  •  1991  |  View Paper
In contrast, the combination of suboptimal doses of CGT (64.0 mmol/kg) and HPR (0.75 mmol/kg) administered daily for 25 days decreased tumor sizes by 33%.
They show that CGT and HPR act synergistically.
Journal of the National Cancer Institute  •  1989  |  View Paper
In contrast, the combination of calcium glucarate (32 mmol/kg) and N-(4-hydroxyphenyl)retinamide ( 0.75 mmol/kg) inhibited tumor incidence and tumor multiplicity by 50%.
Similar synergism was observed with the combination of calcium glucarate (64 mmol/kg) and N-(4-hydroxyphenyl)retinamide ( 0.75 mmol/kg), the inhibition being 55-60%.
Proceedings of the National Academy of Sciences of the United States of America  •  1988  |  View Paper