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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Calcium Glucarate
drug:
Fenretinide
Research Papers that Mention the Interaction
“The apparent higher efficacy of HPR in combination with glucarate (GT) compared to the single agents could be due to increased net formation of HPR glucuronide conjugate following conversion of GT to the beta-glucuronidase inhibitor, D-glucaro-1,4-lactone.”
Growth suppression of human breast carcinoma cells in culture by N-(4-hydroxyphenyl)retinamide and its glucuronide and through synergism with glucarate.“In contrast, the combination of suboptimal doses of CGT (64.0 mmol/kg) and HPR (0.75 mmol/kg) administered daily for 25 days decreased tumor sizes by 33%.”
“They show that CGT and HPR act synergistically.”
Chemotherapeutic evaluation of glucarate and N-(4-hydroxyphenyl)retinamide alone and in combination in the rat mammary tumor model.“In contrast, the combination of calcium glucarate (32 mmol/kg) and N-(4-hydroxyphenyl)retinamide ( 0.75 mmol/kg) inhibited tumor incidence and tumor multiplicity by 50%.”
“Similar synergism was observed with the combination of calcium glucarate (64 mmol/kg) and N-(4-hydroxyphenyl)retinamide ( 0.75 mmol/kg), the inhibition being 55-60%.”
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