Possible Interaction: Calcium Citrate and Calcium Supplement

“Comparison of response curves revealed significantly (p<0.01) more marked Ca increase and PTH suppression with CC than with the other three Ca salts.”

“Urinary excretion of calcium was significantly higher (P < 0.017) at 4 h after supplementation with calcium citrate (0.83 +/- 0.12 mumol Ca/mumol creatinine) compared with calcium carbonate (0.40 +/- 0.11).”

“In vivo study demonstrated that fortification and calcium citrate nano-fortified milk powder increased absorption and bioavailability of calcium , as well as bone stiffness and bone strength in sham, ovariectomized, and ovariectomized-osteoporosis rats.”

“Iron was labeled with the radioisotopes 59Fe or 55Fe, and the absorption of iron was measured by erythrocyte incorporation of radioactive Fe RESULTS: 800 mg of elemental calcium as calcium citrate produced a significant decrease in non-heme iron bioavailability (repeated measures ANOVA, F = 3.79, p = 0.018).”

“We conclude that, in this group of Chinese type 2 diabetic patients in our study, the oral administration of 1200 mg elemental calcium in either calcium citrate or calcium carbonate preparation can induce a significant suppression of i-PTH.”

“ Calcium citrate increased urinary calcium from 3.27 +/- 0.42 mmol.”

“Moreover, the increment in urinary calcium post‐load was higher from calcium citrate than from calcium carbonate at all four dosage levels.”

“The urinary calcium following calcium citrate load significantly higher (by 20-66%), whether expressed as the total amount or as the increment above basal (fasting) excretion.”

“More calcium is absorbed from calcium citrate compared to calcium carbonate.”