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“Therefore, the findings that calcium antagonists could dose-dependently throttle the insulin output after addition of glucose in pancreas perfusion experiments in vitro were of considerable concern.”
Hormone and metabolic research. Supplement series • 1990 | View Paper
“1 Calcium antagonists acutely inhibit in vitro and in vivo the glucose- and sulfonylurea-induced insulin release, apparently by interfering with calcium entry into the beta cell.”
“The degree of inhibition of glucose-induced insulin release by a given concentration of verapamil decreases as the length of exposure to glucose is increased prior to introduction of the calcium antagonist.”