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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
Research Papers that Mention the Interaction
“Behavioral sensitization to cocaine was blocked by coadministration of nimodipine, anL-type calcium channel blocker.”
Behavioral sensitization and tolerance to cocaine and the occupation of dopamine receptors by dopamine“These findings support the use of calcium channel blockers as a strategy to minimize the neurotoxic effects of cocaine.”
“Furthermore, calcium blocker , nifedipine, blocks the effect of cocaine , suggesting that extracellular calcium enters the cytosol through the L-channel.”
“The mechanism of increased cocaine toxicity by CCBs remains to be determined.”
“The calcium channel blockers (CCBs) have been shown to be effective in attenuating the behavioral effects of cocaine in rodents and subjective effects in cocaine-using volunteers.”
“There have been reports indicating that, in the presence of toxic doses of cocaine , the CCBs could actually potentiate cocaine toxicity in rats.”
“All three calcium channel blockers antagonized the pressor effect, but were ineffective against the tachycardiac effect of cocaine.”
“The pressor response to cocaine was attenuated by calcium channel blockers , clonidine, phentolamine and dl- or l-propranolol, but not by d-propranolol.”
“Since calcium antagonists have been reported to exert a protective effect against the cardiovascular disorders induced by cocaine , we tested the hypothesis that this protective action occurs in the microcirculation.”
“The results indicate that various classes of calcium antagonists differ in their interaction with the effects of cocaine in the CNS and suggest that dihydropyridine calcium channel antagonists might be clinically useful for the treatment of cocaine abuse.”
“When added to striatal membrane preparations, flunarizine displaced [3H]spiperone … 100 nM. Since recent evidence indicates that the effects of cocaine are … dihydropyridine calcium antagonists , these findings suggest that the paradoxical potentiating effect of flunarizine is probably … the DA system and is not due to its calcium antagonist property.”
“ Calcium channel blockers appear to reduce the cardiac toxicity of cocaine and some stimulant-induced behaviors.”
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