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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Calcium Carbonate
drug:
Sevelamer
Research Papers that Mention the Interaction
“The dose of concomitantly administered calcium carbonate and sevelamer hydrochloride was reduced.”
Efficacy of Continuous Oral Administration of Lanthanum Carbonate over 24 months“Both the number of cases to which calcium carbonate was administered and their dosages decreased to about 70–80% 12 months after the initiation, and cases administered sevelamer decreased to about 30%.”
“A patient treated with sevelamer gains , on average, 6.34 QALYs relative to no treatment, whereas a patient taking calcium carbonate gains 5.81 QALYs.”
“Metabolic acidosis was not observed in four patients (serum HCO3– level: 20.3 ± 0.7 mmol/L) likely because they were taking 3 g of calcium carbonate with SH.”
“At study completion, serum phosphate levels were lower in the sevelamer arm (median dosages, 4,800 and 2,000 mg/d for sevelamer and calcium carbonate , respectively).”
“ SV prescription was associated with higher mortality than CaCO3 (HR, 1.46 [1.1–1.9]).”
“We therefore consider it advisable to use sevelamer hydrochloride in combination with calcium carbonate in hemodialysis patients.”
“The suppressive effect of the switching from calcium carbonate to sevelamer hydrochloride on the progression of vascular calcification was examined by measuring areas of calcification on routine chest X-rays using image-analyzing software.”
“While the usefulness of computed tomography in detecting vascular calcification … has been reported previously, the suppressive effects of switching from calcium carbonate … sevelamer hydrochloride on the progression of aortic calcification can be observed without computed tomography by … plain chest X-ray films that are routinely performed in hemodialysis clinics.”
“During calcium carbonate treatment plasma phosphate concentrations were significantly below those of patients on sevelamer.”
“The combination of sevelamer hydrochloride and CaCO3 is a suitable regimen for hyperphosphatemia treatment in HD patients because it avoids both the hypercalcemia of CaCO3 and the adverse effects of sevelamer hydrochloride when each is used as single‐drug therapy.”
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