Possible Interaction: Calcium Carbonate and Phosphorus

“Reduction in serum phosphorous were observed with calcium acetate (1.5 mg/dL), calcium carbonate (1.3 mg/dL), sevelamer hydrochloride (2.1 mg/dL) and lanthanum carbonate (1.79 mg/dL).”

“ Phosphorus leaching from the soils amended with CaCl2 or CaCl2+CaCO3 was less but more persistent than that of other amendments.”

“ Calcium carbonate doses were increased from 2.3 (median, range 0.75-… 6.8 (3.8-15.0, p = 0.0004) and serum phosphorus concentrations decreased from 2.00 mmol/l (median, range 1.25-2.67) … 1.61 (1.18-2.39) at 24 weeks (p = 0.023).”

“A few patients ingesting large amounts of calcium carbonate to control their extremely high phosphorus levels developed hypercalcemia.”

“Treatments with cross-linked chitosan iron (III) and calcium carbonate prevented phosphorus increase (20%–30% reduction).”

“ Serum phosphorus was reduced with CaCO3 3% (2.06 mM; P ≤ 0.001), PA21 1.5% (2.29 mM; P < 0.05), and PA21 5% (2.21 mM; P ≤ 0.001) versus CRF controls (2.91 mM).”

“In the rat dietary phosphorus excretion experiments, PAA-B, Dowex 1x8, and CaCO3 increased fecal phosphorus excretion by 62.7, 32.3, and 84.0%, respectively.”

“However, the low SRP levels in the groundwater coupled with calcite saturation, may well indicate that phosphorous concentrations within the groundwater are regulated by such processes: the number of calcite nucleating sites are orders of magnitude higher and the calcite inhibitors may be less prevalent.”