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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Calcium Carbonate
drug:
Ofloxacin
Research Papers that Mention the Interaction
“Co-administration of 500 mg/L CaCO3 to healthy volunteers significantly reduced the urinary excretion of 250 mg/L ciprofloxacin but not 200 mg/L ofloxacin although neither the fraction of absorbed dose nor the half-lives were markedly affected.”
“In intestinal sacs, the presence of 5000 mg/L CaCO3 significantly reduced both the absorption constant and the fraction of absorbed dose of 2000 mg/L ciprofloxacin but not 2000 mg/L ofloxacin.”
“When the same concentration of CaCO3 was introduced into the isolated intestinal segments of rats, the absorption of both 200 mg/L ofloxacin and 400 mg/L ciprofloxacin was reduced significantly from 49% and 35% respectively to approximately 30% in each case.”
Comparative study of the influence of Ca2+ on absorption parameters of ciprofloxacin and ofloxacin.“In-vitro studies using simulated gastric fluid showed that ferrous sulphate, aluminium hydroxide and calcium carbonate reduced ofloxacin availability to 67.4%, 69.3% and 73.8%, respectively.”
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