Possible Interaction: Calcium Carbonate and Calcium Supplement

“A significant increase in calcium plasma levels was only observed after treatment with calcium carbonate [9.34 mg/dl (SD 0.91) vs. 9.91 mg/dl (SD 0.79), P < 0.01].”

“Also, administration of CaCO3 before a meal is associated with significantly lower plasma corrected calcium , suggesting less absorption of calcium, which may be an advantage but only in hypercalcemic patients.”

“The presence of calcium ions stimulates precipitation of calcium carbonate in the wound area and thereby contributes to the initiation of mineralization.”

“There have been many reports of milk alkali syndrome from calcium carbonate intake ranging from 1 to 9 g of elemental calcium per day.”

“Supplementing 500 mg Ca as calcium carbonate significantly (P = 0.0009) reduced Fe absorption from a single meal from 10.2 % (range 2.2-40.6) to 4.8 % (range 0.7-18.9).”

“Patients on CaCO3 had significantly higher serum Ca 2.38 +/- 0.31 mmol/L than those on CaAc therapy 2.26 +/- 0.22 mmol/L. CONCLUSION Most of patients on maintenance haemodialysis at Rawalpindi, did not achieve the recommended K/DOQI target ranges.”

“However, the addition of CaCO3 significantly reduced serum Pi at Week 8 compared to that at Week 0 in both groups, and significantly lowered Ca × P only in the sevelamer group, but not in the colestimide group.”

“An inverse relation was seen between the inhibitory effect of calcium carbonate and calcium oxalate and their time of introduction into the system.”

“However, considering the calcium load , the excessive dosing of calcium carbonate must be avoided.”

“We conclude that, in this group of Chinese type 2 diabetic patients in our study, the oral administration of 1200 mg elemental calcium in either calcium citrate or calcium carbonate preparation can induce a significant suppression of i-PTH.”