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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tretinoin
Research Papers that Mention the Interaction
“ Retinoic acid treatment of the CA77 thyroid C-cell line decreased CT/CGRP promoter activity two- to threefold, which correlates well with the decrease in calcitonin and CGRP mRNA levels.”
“We have investigated the mechanism underlying repression of calcitonin/calcitonin gene-related peptide (CT/CGRP) gene expression by retinoic acid.”
Retinoic acid repression of cell-specific helix-loop-helix-octamer activation of the calcitonin/calcitonin gene-related peptide enhancer.“Dex alone (10(-6) M) elicited a 2-fold increase in CGRP mRNA and a 9-… mRNA steady state levels after 6 days of treatment whereas addition of 5.10(-5) M R.A. alone for … both the CGRP and the CT mRNA steady …- and 4-fold decreases, respectively).”
“Our results showed that 5.10(-7) M R.A. blunted in part (-30%) the rise of CT and CGRP mRNA induced under Dex; whereas doses > or = 5.10(-6) M maximally decreased both CT and CGRP mRNA (2- and 9-fold decreases, respectively).”
Steroid hormones and retinoic acid interact in the regulation of calcitonin and calcitonin gene-related peptide secretion and messenger ribonucleic acid levels in CA-77 C cells.
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