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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
Research Papers that Mention the Interaction
“Sex steroid hormones, estrogens and progesterone , regulate CGRP synthesis and its effects on both myometrial and uterine vascular tissues.”
Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity“ Progesterone increased both CGRP and SP levels in females.”
Effects of estrogen and progesterone on the neurogenic inflammatory neuropeptides: implications for gender differences in migraine.“Phosphodiesterase inhibition by 3-isobutyl-1-methylxanthine enhances the CGRP response while adenyl cyclase inhibition by either 2′,5′-dideoxyadenosine or progesterone nearly completely depresses the CGRP response.”
“We hypothesized that endogenous CGRP is required for maintaining blood pressure and fetoplacental growth in pregnant rats, and that progesterone will enhance CGRP effects.”
“… CGRP … progesterone (P < 0.05), 2) acute hypotensive effects of CGRP were significantly (P < 0.05) greater in the presence of steroid hormones than in vehicle-… adult ovariectomized rats, and 4) age-related differences in the hypotensive effects of CGRP were nullified when animals were treated with steroid hormones.”
“The combination of CGRP with progesterone decreased BP to control levels in the post-partum period, and also significantly improved foetal mortality and growth (P < 0.05).”
“Therefore we conclude that progesterone modulates vasodilator effects of calcitonin gene-related peptide in hypertensive rats.”
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