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Immunopharmacology and immunotoxicology • 2001 | View Paper
“In immunoneutralization studies (n = 6) using a high-affinity somatostatin antibody, the inhibitory effect of CGRP at 10−8 M was reversed to a significant stimulation of insulin and glucagon secretion.”
“Preincubation with αCGRP8–37(10−7 –10−5 M) and a novel nonpeptide CGRP antagonist “Compound 1” (WO98/11128) 10−7–10−5 M ) caused a dose-dependent rightward shift of the concentration-response curves for αCGRP with pA 2 values of 7.0 and 7.1, respectively.”